Selected Publications from the Ober Lab
Spinal muscular atrophy among US Hutterites: Phenotype variability in the setting of conserved ancestral haplotype and 4 SMN2 copies.
Butchbach MER, Kale JJ, Simeone SD, Chen JYH, Anderson RL, Prichina AY, Del Gaudio D, Stabley DL, Holbrook J, Culcea E, Ober C, Swoboda KJ.
(2026)
Genet Med. 28(4):102535. doi: 10.1016/j.gim.2026.102535. Online ahead of print.
PMID: 41691542Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children.
Thompson EE, Zhong X, Carbonetto P, Morin A, Willwerscheid J, Visness CM, Bacharier LB, Kattan M, O'Connor GT, Rivera-Spoljaric K, Wood RA, Gold DR, Khurana Hershey GK, Johnson CC, Miller RL, Seroogy CM, Zoratti EM, Gergen PJ, Levin AM, Altman MC, Hartert T, Stephens M, Jackson DJ, Gern JE, McKennan CG, Ober C.
Prenatal ambient air pollution associations with DNA methylation in asthma- and allergy-relevant genes: findings from ECHO.
Palmore M, Thompson EE, Fang F, Bastain TM, Breton C, Collingwood S, Gilliland FD, Gold DR, Habre R, Hartert T, Khurana Hershey GK, Jackson DJ, Miller R, Ryan P, Shorey-Kendrick L, Spindel ER, Stanford J, Gern J, McKennan C, Ober C, Ladd-Acosta C.
Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations.
Zhong X, Mitchell R, Billstrand C, Thompson EE, Sakabe NJ, Aneas I, Salamone IM, Gu J, Sperling AI, Schoettler N, Nóbrega MA, He X, Ober C.
Rhinovirus infection of airway epithelial cells uncovers the non-ciliated subset as a likely driver of genetic risk to childhood-onset asthma.
Djeddi S, Fernandez-Salinas D, Huang GX, Aguiar VRC, Mohanty C, Kendziorski C, Gazal S, Boyce JA, Ober C, Gern JE, Barrett NA, Gutierrez-Arcelus M.
Multitasking within the airway epithelium.
Gern JE, Ober C.
(2024)
Eur Respir J. 63(5):2302223. doi: 10.1183/13993003.02223-2023. Print 2024 May.
PMID: 38697632Population descriptors in asthma and allergy research: Time to regroup.
Ober C, Joseph CLM, Novembre J.
(2024)
J Allergy Clin Immunol. 154(1):79-81. doi: 10.1016/j.jaci.2024.04.003. Epub 2024 Apr 18.
PMID: 38642714Screening asthmatics for atopic status using the ALergy EXplorer (ALEX(2)) macroarray.
Hamilton RG, Holbreich M, Bronzert C, Anderson RL, Schoettler N, Ober C.
(2024)
J Asthma. 61(9):1050-1057. doi: 10.1080/02770903.2024.2324839. Epub 2024 Mar 5.
PMID: 38415683Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
Clay S, Alladina J, Smith NP, Visness CM, Wood RA, O'Connor GT, Cohen RT, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Gill MA, Liu AH, Kim H, Kattan M, Bacharier LB, Rastogi D, Rivera-Spoljaric K, Robison RG, Gergen PJ, Busse WW, Villani AC, Cho JL, Medoff BD, Gern JE, Jackson DJ, Ober C, Dapas M.
Revealing polygenic pleiotropy using genetic risk scores for asthma.
Dapas M, Lee YL, Wentworth-Sheilds W, Im HK, Ober C, Schoettler N.
Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis.
Soliai MM, Kato A, Naughton KA, Norton JE, Klinger AI, Kern RC, Tan BK, Nicolae DL, Schleimer RP, Ober C, Pinto JM.
Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1(+) non-immune cells in human spontaneous preterm labor.
Liu X, Aneas I, Sakabe N, Anderson RL, Billstrand C, Paz C, Kaur H, Furner B, Choi S, Prichina AY, Enninga EAL, Dong H, Murtha A, Crawford GE, Kessler JA, Grobman W, Nobrega MA, Rana S, Ober C.
A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome.
Morin A, Thompson EE, Helling BA, Shorey-Kendrick LE, Faber P, Gebretsadik T, Bacharier LB, Kattan M, O'Connor GT, Rivera-Spoljaric K, Wood RA, Barnes KC, Mathias RA, Altman MC, Hansen K, McEvoy CT, Spindel ER, Hartert T, Jackson DJ, Gern JE, McKennan CG, Ober C; program collaborators for Environmental Influences on Child Health Outcomes and Children’s Respiratory and Environmental Workgroup.
Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.
Dapas M, Thompson EE, Wentworth-Sheilds W, Clay S, Visness CM, Calatroni A, Sordillo JE, Gold DR, Wood RA, Makhija M, Khurana Hershey GK, Sherenian MG, Gruchalla RS, Gill MA, Liu AH, Kim H, Kattan M, Bacharier LB, Rastogi D, Altman MC, Busse WW, Becker PM, Nicolae D, O'Connor GT, Gern JE, Jackson DJ, Ober C.
African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans.
Washington C 3rd, Dapas M, Biddanda A, Magnaye KM, Aneas I, Helling BA, Szczesny B, Boorgula MP, Taub MA, Kenny E, Mathias RA, Barnes KC; CAAPA; Khurana Hershey GK, Kercsmar CM, Gereige JD, Makhija M, Gruchalla RS, Gill MA, Liu AH, Rastogi D, Busse W, Gergen PJ, Visness CM, Gold DR, Hartert T, Johnson CC, Lemanske RF Jr, Martinez FD, Miller RL, Ownby D, Seroogy CM, Wright AL, Zoratti EM, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Nobrega MA, Altman MC, Jackson DJ, Gern JE, McKennan CG, Ober C.
Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women.
Chung J, Das A, Sun X, Sobreira DR, Leung YY, Igartua C, Mozaffari S, Chou YF, Thiagalingam S, Mez J, Zhang X, Jun GR, Stein TD, Kunkle BW, Martin ER, Pericak-Vance MA, Mayeux R, Haines JL, Schellenberg GD, Nobrega MA, Lunetta KL, Pinto JM, Wang LS, Ober C, Farrer LA.
DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.
Magnaye KM, Clay SM, Nicodemus-Johnson J, Naughton KA, Huffman J, Altman MC, Jackson DJ, Gern JE, Hogarth DK, Naureckas ET, White SR, Ober C.
Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region.
Clay SM, Schoettler N, Goldstein AM, Carbonetto P, Dapas M, Altman MC, Rosasco MG, Gern JE, Jackson DJ, Im HK, Stephens M, Nicolae DL, Ober C.
New Insights Relating Gasdermin B to the Onset of Childhood Asthma.
Schoettler N, Dissanayake E, Craven MW, Yee JS, Eliason J, Schauberger EM, Lemanske RF Jr, Ober C, Gern JE.
17q12-q21 variants interact with early-life exposures to modify asthma risk in Black children.
Gereige JD, Morin A, Calatroni A, Visness CM, Wood RA, Kattan M, Bacharier LB, Becker P, Altman MC, Gern JE, Ober C, O'Connor GT.
Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Soliai MM, Kato A, Helling BA, Stanhope CT, Norton JE, Naughton KA, Klinger AI, Thompson EE, Clay SM, Kim S, Celedón JC, Gern JE, Jackson DJ, Altman MC, Kern RC, Tan BK, Schleimer RP, Nicolae DL, Pinto JM, Ober C.
A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma.
Magnaye KM, Naughton KA, Huffman J, Hogarth DK, Naureckas ET, White SR, Ober C.
(2021)
Eur Respir J. 58(1):2003862. doi: 10.1183/13993003.03862-2020. Print 2021 Jul.
PMID: 33446603Sex-specific differences in peripheral blood leukocyte transcriptional response to LPS are enriched for HLA region and X chromosome genes.
Stein MM, Conery M, Magnaye KM, Clay SM, Billstrand C, Nicolae R, Naughton K, Ober C, Thompson EE.
Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.
Sakabe NJ, Aneas I, Knoblauch N, Sobreira DR, Clark N, Paz C, Horth C, Ziffra R, Kaur H, Liu X, Anderson R, Morrison J, Cheung VC, Grotegut C, Reddy TE, Jacobsson B, Hallman M, Teramo K, Murtha A, Kessler J, Grobman W, Zhang G, Muglia LJ, Rana S, Lynch VJ, Crawford GE, Ober C, He X, Nóbrega MA.
Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma.
Helling BA, Sobreira DR, Hansen GT, Sakabe NJ, Luo K, Billstrand C, Laxman B, Nicolae RI, Nicolae DL, Bochkov YA, Gern JE, Nobrega MA, White SR, Ober C.
Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels.
McKennan C, Naughton K, Stanhope C, Kattan M, O'Connor GT, Sandel MT, Visness CM, Wood RA, Bacharier LB, Beigelman A, Lovinsky-Desir S, Togias A, Gern JE, Nicolae D, Ober C.
Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Thompson EE, Dang Q, Mitchell-Handley B, Rajendran K, Ram-Mohan S, Solway J, Ober C, Krishnan R.
Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age.
Morin A, McKennan CG, Pedersen CT, Stokholm J, Chawes BL, Malby Schoos AM, Naughton KA, Thorsen J, Mortensen MS, Vercelli D, Trivedi U, Sørensen SJ, Bisgaard H, Nicolae DL, Bønnelykke K, Ober C.
Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Ober C, McKennan CG, Magnaye KM, Altman MC, Washington C 3rd, Stanhope C, Naughton KA, Rosasco MG, Bacharier LB, Billheimer D, Gold DR, Gress L, Hartert T, Havstad S, Khurana Hershey GK, Hallmark B, Hogarth DK, Jackson DJ, Johnson CC, Kattan M, Lemanske RF, Lynch SV, Mendonca EA, Miller RL, Naureckas ET, O'Connor GT, Seroogy CM, Wegienka G, White SR, Wood RA, Wright AL, Zoratti EM, Martinez FD, Ownby D, Nicolae DL, Levin AM, Gern JE; Environmental Influences on Child Health Outcomes-Children's Respiratory Research Workgroup.
T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.
Hrusch CL, Stein MM, Gozdz J, Holbreich M, von Mutius E, Vercelli D, Ober C, Sperling AI.
Effects of an FcγRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.
Stein MM, Hrusch CL, Sperling AI, Ober C.
Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells.
Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C.
Genetic architecture of moderate-to-severe asthma mirrors that of mild asthma.
Schoettler N, Ober C.
(2019)
J Allergy Clin Immunol. 144(6):1521-1523. doi: 10.1016/j.jaci.2019.09.003. Epub 2019 Sep 18.
PMID: 31541629Advances in asthma and allergic disease genetics: Is bigger always better?
Schoettler N, Rodríguez E, Weidinger S, Ober C.
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK.
Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.
Mozaffari SV, DeCara JM, Shah SJ, Sidore C, Fiorillo E, Cucca F, Lang RM, Nicolae DL, Ober C.
Lessons Learned From GWAS of Asthma.
Kim KW, Ober C.
The Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium: design, methods, and study population.
Gern JE, Jackson DJ, Lemanske RF Jr, Seroogy CM, Tachinardi U, Craven M, Hwang SY, Hamilton CM, Huggins W, O'Connor GT, Gold DR, Miller R, Kattan M, Johnson CC, Ownby D, Zoratti EM, Wood RA, Visness CM, Martinez F, Wright A, Lynch S, Ober C, Khurana Hershey GK, Ryan P, Hartert T, Bacharier LB.
A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle.
Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Morin A, Washington C 3rd, Nicolae D, Bønnelykke K, Ober C.
Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions.
Mozaffari SV, Stein MM, Magnaye KM, Nicolae DL, Ober C.
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA; Australian Asthma Genetics Consortium (AAGC) collaborators; Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, et al.
Immune development and environment: lessons from Amish and Hutterite children.
Ober C, Sperling AI, von Mutius E, Vercelli D.
Rare non-coding variants are associated with plasma lipid traits in a founder population.
Igartua C, Mozaffari SV, Nicolae DL, Ober C.
Host genetic variation in mucosal immunity pathways influences the upper airway microbiome.
Igartua C, Davenport ER, Gilad Y, Nicolae DL, Pinto J, Ober C.
DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Nicodemus-Johnson J, Myers RA, Sakabe NJ, Sobreira DR, Hogarth DK, Naureckas ET, Sperling AI, Solway J, White SR, Nobrega MA, Nicolae DL, Gilad Y, Ober C.
Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Ober C, Sperling AI.
Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways.
Nicodemus-Johnson J, Naughton KA, Sudi J, Hogarth K, Naurekas ET, Nicolae DL, Sperling AI, Solway J, White SR, Ober C.
Integrated analyses of gene expression and genetic association studies in a founder population.
Cusanovich DA, Caliskan M, Billstrand C, Michelini K, Chavarria C, De Leon S, Mitrano A, Lewellyn N, Elias JA, Chupp GL, Lang RM, Shah SJ, Decara JM, Gilad Y, Ober C.
Leveraging gene-environment interactions and endotypes for asthma gene discovery.
Bønnelykke K, Ober C.
Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes.
Burrows CK, Kosova G, Herman C, Patterson K, Hartmann KE, Velez Edwards DR, Stephenson MD, Lynch VJ, Ober C.
Genetic associations with viral respiratory illnesses and asthma control in children.
Loisel DA, Du G, Ahluwalia TS, Tisler CJ, Evans MD, Myers RA, Gangnon RE, Kreiner-Møller E, Bønnelykke K, Bisgaard H, Jackson DJ, Lemanske RF Jr, Nicolae DL, Gern JE, Ober C.
Genome-wide association study of recalcitrant atopic dermatitis in Korean children.
Kim, K.W., Myers, R.A., Lee, J.H., Igartua, C., Lee, K.E., Kim, Y.H., Kim, E.J., Yoon, D., Lee, J.S., Hirota, T., Tamari, M., Takahashi, A., Kubo, M., Choi, J.M., Kim, K.E., Nicolae, D.L., Ober, C. & Sohn, M.H.
Genome-Wide Association Studies of the Human Gut Microbiota.
Davenport ER, Cusanovich DA, Michelini K, Barreiro LB, Ober C, Gilad Y.
Host genetic variation influences gene expression response to rhinovirus infection.
Çalışkan M, Baker SW, Gilad Y, Ober C.
PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population.
Livne OE, Han L, Alkorta-Aranburu G, Wentworth-Sheilds W, Abney M, Ober C, Nicolae DL.
An estimate of the average number of recessive lethal mutations carried by humans.
Gao Z, Waggoner D, Stephens M, Ober C, Przeworski M.
Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma.
Igartua C, Myers RA, Mathias RA, Pino-Yanes M, Eng C, Graves PE, Levin AM, Del-Rio-Navarro BE, Jackson DJ, Livne OE, Rafaels N, Edlund CK, Yang JJ, Huntsman S, Salam MT, Romieu I, Mourad R, Gern JE, Lemanske RF, Wyss A, Hoppin JA, Barnes KC, Burchard EG, Gauderman WJ, Martinez FD, Raby BA, Weiss ST, Williams LK, London SJ, Gilliland FD, Nicolae DL, Ober C.
Disclosure of genetic research results to members of a founder population.
Anderson RL, Murray K, Chong JX, Ouwenga R, Antillon M, Chen P, Diaz de Leon L, Swoboda KJ, Lester LA, Das S, Ober C, Waggoner DJ.
Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.
Campbell CD, Mohajeri K, Malig M, Hormozdiari F, Nelson B, Du G, Patterson KM, Eng C, Torgerson DG, Hu D, Herman C, Chong JX, Ko A, O'Roak BJ, Krumm N, Vives L, Lee C, Roth LA, Rodriguez-Cintron W, Rodriguez-Santana J, Brigino-Buenaventura E, Davis A, Meade K, LeNoir MA, Thyne S, Jackson DJ, Gern JE, Lemanske RF, Jr., Shendure J, Abney M, Burchard EG, Ober C, Eichler EE.
The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines.
Caliskan M, Pritchard JK, Ober C, Gilad Y.
Genome-wide interaction studies reveal sex-specific asthma risk alleles.
Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, Del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B, Salam MT, Torgerson DG, Van den Berg DJ, Vora H, Bleecker ER, Meyers DA, Williams LK, Martinez FD, Burchard EG, Barnes KC, on behalf of G, Gilliland FD, Weiss ST, London SJ, Raby BA, Ober C, Nicolae DL.
(2014)
Hum Mol Genet. 23(19):5251-9.
PMID: Lifecourse Epidemiology C, Casula S, Biino G, Dizier MH, Pin I, Matran R, Lathrop M, Pirastu M, Demenais F, Ober C. A Common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults.
Bouzigon E, Nadif R, Thompson EE, Concas MP, Kuldanek S, Du G, Brossard M, Lavielle N, Sarnowski C, Vaysse A, Dessen P, van der Valk RJ, Duijts L, Henderson AJ, Jaddoe VW, de Jongste JC, consortium G, Genetics EA,
(2014)
Clin Exp Allergy. .
PMID: Seasonal variation in human gut microbiome composition.
Davenport ER, Mizrahi-Man O, Michelini K, Barreiro LB, Ober C, Gilad Y.
Variants in DPF3 and DSCAML1 are associated with sperm morphology.
Kosova G, Hotaling JM, Ohlander S, Niederberger C, Prins GS, Ober C.
Genome-wide association study of lung function phenotypes in a founder population.
Yao TC, Du G, Han L, Sun Y, Hu D, Yang JJ, Mathias R, Roth LA, Rafaels N, Thompson EE, Loisel DA, Anderson R, Eng C, Arruabarrena Orbegozo M, Young M, Klocksieben JM, Anderson E, Shanovich K, Lester LA, Williams LK, Barnes KC, Burchard EG, Nicolae DL, Abney M, Ober C.
Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile.
Abe K, Ohno Y, Sassa T, Taguchi R, Çalışkan M, Ober C, Kihara A.
Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.
Gerull B, Kirchner F, Chong JX, Tagoe J, Chandrasekharan K, Strohm O, Waggoner D, Ober C, Duff HJ.
(2013)
Circ Cardiovasc Genet. 6(4):327-36. doi: 10.1161/CIRCGENETICS.113.000097. Epub 2013 Jul 17.
PMID: 23863954Recessive TRAPPC11 mutations cause a disease spectrum of limb girdle muscular dystrophy and myopathy with movement disorder and intellectual disability.
Bögershausen N, Shahrzad N, Chong JX, von Kleist-Retzow JC, Stanga D, Li Y, Bernier FP, Loucks CM, Wirth R, Puffenberger EG, Hegele RA, Schreml J, Lapointe G, Keupp K, Brett CL, Anderson R, Hahn A, Innes AM, Suchowersky O, Mets MB, Nürnberg G, McLeod DR, Thiele H, Waggoner D, Altmüller J, Boycott KM, Schoser B, Nürnberg P, Ober C, Heller R, Parboosingh JS, Wollnik B, Sacher M, Lamont RE.
Intellectual disability associated with a homozygous missense mutation in THOC6.
Beaulieu CL, Huang L, Innes AM, Akimenko MA, Puffenberger EG, Schwartz C, Jerry P, Ober C, Hegele RA, McLeod DR, Schwartzentruber J; FORGE Canada Consortium; Majewski J, Bulman DE, Parboosingh JS, Boycott KM.
Human spermatogenic failure purges deleterious mutation load from the autosomes and both sex chromosomes, including the gene DMRT1.
Lopes AM, Aston KI, Thompson E, Carvalho F, Gonçalves J, Huang N, Matthiesen R, Noordam MJ, Quintela I, Ramu A, Seabra C, Wilfert AB, Dai J, Downie JM, Fernandes S, Guo X, Sha J, Amorim A, Barros A, Carracedo A, Hu Z, Hurles ME, Moskovtsev S, Ober C, Paduch DA, Schiffman JD, Schlegel PN, Sousa M, Carrell DT, Conrad DF.
Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Nicodemus-Johnson J, Laxman B, Stern RK, Sudi J, Tierney CN, Norwick L, Hogarth DK, McConville JF, Naureckas ET, Sperling AI, Solway J, Krishnan JA, Nicolae DL, White SR, Ober C.
Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.
Calışkan M, Bochkov YA, Kreiner-Møller E, Bønnelykke K, Stein MM, Du G, Bisgaard H, Jackson DJ, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C.
The maternal HLA-G 1597ΔC null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women.
Loisel DA, Billstrand C, Murray K, Patterson K, Chaiworapongsa T, Romero R, Ober C.
Maternal microchimerism protects against the development of asthma.
Thompson EE, Myers RA, Du G, Aydelotte TM, Tisler CJ, Stern DA, Evans MD, Graves PE, Jackson DJ, Martinez FD, Gern JE, Wright AL, Lemanske RF, Ober C.
The ABO blood group is a trans-species polymorphism in primates.
Ségurel L, Thompson EE, Flutre T, Lovstad J, Venkat A, Margulis SW, Moyse J, Ross S, Gamble K, Sella G, Ober C, Przeworski M.
Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.
Myers RA, Himes BE, Gignoux CR, Yang JJ, Gauderman WJ, Rebordosa C, Xie J, Torgerson DG, Levin AM, Baurley J, Graves PE, Mathias RA, Romieu I, Roth LA, Conti D, Avila L, Eng C, Vora H, LeNoir MA, Soto-Quiros M, Liu J, Celedón JC, Galanter JM, Farber HJ, Kumar R, Avila PC, Meade K, Serebrisky D, Thyne S, Rodriguez-Cintron W, Rodriguez-Santana JR, Borrell LN, Lemanske RF Jr, Bleecker ER, Meyers DA, London SJ, Barnes KC, Raby BA, Martinez FD, Gilliland FD, Williams LK, Burchard EG, Weiss ST, Nicolae DL, Ober C.
Estimating the human mutation rate using autozygosity in a founder population.
Campbell CD, Chong JX, Malig M, Ko A, Dumont BL, Han L, Vives L, O'Roak BJ, Sudmant PH, Shendure J, Abney M, Ober C, Eichler EE.
A population-based study of autosomal-recessive disease-causing mutations in a founder population.
Chong JX, Ouwenga R, Anderson RL, Waggoner DJ, Ober C.
Increased protein-coding mutations in the mitochondrial genome of African American women with preeclampsia.
Ding D, Scott NM, Thompson EE, Chaiworapongsa T, Torres R, Billstrand C, Murray K, Dexheimer PJ, Ismail M, Kay H, Levy S, Romero R, Lindheimer MD, Nicolae DL, Ober C.
HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in Iraq.
Jassem RM, Shani WS, Loisel DA, Sharief M, Billstrand C, Ober C.
Genome-wide association study identifies candidate genes for male fertility traits in humans.
Kosova G, Scott NM, Niederberger C, Prins GS, Ober C.
Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects.
Torgerson DG, Capurso D, Ampleford EJ, Li X, Moore WC, Gignoux CR, Hu D, Eng C, Mathias RA, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Rodríguez-Santana JR, Rodríguez-Cintrón W, Avila PC, Ford JG, Barnes KC, Burchard EG, Howard TD, Bleecker ER, Meyers DA, Cox NJ, Ober C, Nicolae DL.
XM: association testing on the X-chromosome in case-control samples with related individuals.
Thornton T, Zhang Q, Cai X, Ober C, McPeek MS.
Evaluating the evidence for transmission distortion in human pedigrees.
Meyer WK, Arbeithuber B, Ober C, Ebner T, Tiemann-Boege I, Hudson RR, Przeworski M.
Accurate imputation of rare and common variants in a founder population from a small number of sequenced individuals.
Uricchio LH, Chong JX, Ross KD, Ober C, Nicolae DL.
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
Cusanovich DA, Billstrand C, Zhou X, Chavarria C, De Leon S, Michelini K, Pai AA, Ober C, Gilad Y.
Resequencing candidate genes implicates rare variants in asthma susceptibility.
Torgerson DG, Capurso D, Mathias RA, Graves PE, Hernandez RD, Beaty TH, Bleecker ER, Raby BA, Meyers DA, Barnes KC, Weiss ST, Martinez FD, Nicolae DL, Ober C.
Rising prevalence of asthma is sex-specific in a US farming population.
Motika CA, Papachristou C, Abney M, Lester LA, Ober C.
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, Baurley JW, Eng C, Stern DA, Celedón JC, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, Li X, Myers RA, Romieu I, Van Den Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque MU, Dunston GM, Watson HR, Mantese VJ, Ezurum SC, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sienra-Monge JJ, del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske RF Jr, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ; Mexico City Childhood Asthma Study (MCAAS); Gilliland FD; Children's Health Study (CHS) and HARBORS study; Burchard EG; Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE); Martinez FD; Childhood Asthma Research and Education (CARE) Network; Weiss ST; Childhood Asthma Management Program (CAMP); Williams LK; Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE); Barnes KC; Genetic Research on Asthma in African Diaspora (GRAAD) Study; Ober C, Nicolae DL.
IFNG genotype and sex interact to influence the risk of childhood asthma.
Loisel DA, Tan Z, Tisler CJ, Evans MD, Gangnon RE, Jackson DJ, Gern JE, Lemanske RF Jr, Ober C.
(2011)
J Allergy Clin Immunol. 128(3):524-31. Epub 2011 Jul 27.
PMID: 2179857The genetics of asthma and allergic disease: a 21st century perspective.
Ober C, Yao TC.
Exome sequencing and the genetics of intellectual disability.
Topper S, Ober C, Das S.
(2011)
Clin Genet. 80(2):117-26. doi:10.1111/j.1399-0004.2011.01720.x. Epub 2011 Jun 15.
PMID: 21627642A common spinal muscular atrophy deletion mutation is present on a single founder haplotype in the US Hutterites.
Chong JX, Oktay AA, Dai Z, Swoboda KJ, Prior TW, Ober C.
Genetic variance components estimation for binary traits using multiple related individuals.
Papachristou C, Ober C, Abney M.
The effects of EBV transformation on gene expression levels and methylation profiles.
Caliskan M, Cusanovich DA, Ober C, Gilad Y.
Gene-environment interactions in human disease: nuisance or opportunity?
Ober C, Vercelli D.
Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13.
Çalışkan M, Chong JX, Uricchio L, Anderson R, Chen P, Sougnez C, Garimella K, Gabriel SB, dePristo MA, Shakir K, Matern D, Das S, Waggoner D, Nicolae DL, Ober C.
Sequence variation in the IL4 gene and resistance to Trypanosoma cruzi infection in Bolivians.
Alvarado Arnez LE, Venegas EN, Ober C, Thompson EE.
Blood groups in the species survival plan(R), European endangered species program, and managed in situ populations of bonobo (Pan paniscus), common chimpanzee (Pan troglodytes), gorilla (Gorilla ssp.), and orangutan (Pongo pygmaeus ssp.).
Gamble KC, Moyse JA, Lovstad JN, Ober CB, Thompson EE.
(2011)
Zoo Biol. 30(4):427-44. doi: 10.1002/zoo.20348. Epub 2010 Sep 17.
PMID: 20853409The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate.
Kosova G, Pickrell JK, Kelley JL, McArdle PF, Shuldiner AR, Abney M, Ober C.
Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility.
Sun X, Ma SF, Wade MS, Flores C, Pino-Yanes M, Moitra J, Ober C, Kittles R, Husain AN, Ford JG, Garcia JG.
Getting from genes to function in lung disease: a National Heart, Lung, and Blood Institute workshop report.
Ober C, Butte AJ, Elias JA, Lusis AJ, Gan W, Banks-Schlegel S, Schwartz D.
Levels of soluble human leukocyte antigen-G are increased in asthmatic airways.
White SR, Loisel DA, McConville JF, Stern R, Tu Y, Marroquin BA, Noth I, Ober C.
PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.
Baudat F, Buard J, Grey C, Fledel-Alon A, Ober C, Przeworski M, Coop G, de Massy B.
Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans.
Thompson EE, Sun Y, Nicolae D, Ober C.
Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility.
Haller G, Torgerson DG, Ober C, Thompson EE.
Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes.
Pichler I, Fuchsberger C, Platzer C, Calişkan M, Marroni F, Pramstaller PP, Ober C.
Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors.
Thompson EE, Haller G, Pinto JM, Sun Y, Zelano B, Jacob S, McClintock MK, Nicolae DL, Ober C.
Colloquium papers: Heritability of reproductive fitness traits in a human population.
Kosova G, Abney M, Ober C.
Broad-scale recombination patterns underlying proper disjunction in humans.
Fledel-Alon A, Wilson DJ, Broman K, Wen X, Ober C, Coop G, Przeworski M.
The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases.
Ober C, Chupp GL.
(Too) great expectations: the challenges in replicating asthma disease genes.
Nicolae DL, Ober C.
Linkage analysis with dense SNP maps in isolated populations.
Bellenguez C, Ober C, Bourgain C.
Inverted duplications on acentric markers: mechanism of formation.
Murmann AE, Conrad DF, Mashek H, Curtis CA, Nicolae RI, Ober C, Schwartz S.
Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.
Ober C, Nord AS, Thompson EE, Pan L, Tan Z, Cusanovich D, Sun Y, Nicolae R, Edelstein C, Schneider DH, Billstrand C, Pfaffinger D, Phillips N, Anderson RL, Philips B, Rajagopalan R, Hatsukami TS, Rieder MJ, Heagerty PJ, Nickerson DA, Abney M, Marcovina S, Jarvik GP, Scanu AM, Nicolae DL.
Whole-genome association study identifies STK39 as a hypertension susceptibility gene.
Wang Y, O'Connell JR, McArdle PF, Wade JB, Dorff SE, Shah SJ, Shi X, Pan L, Rampersaud E, Shen H, Kim JD, Subramanya AR, Steinle NI, Parsa A, Ober CC, Welling PA, Chakravarti A, Weder AB, Cooper RS, Mitchell BD, Shuldiner AR, Chang YP.
Sex-specific genetic architecture of human disease.
Ober C, Loisel DA, Gilad Y.
A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.
Pinto JM, Hayes MG, Schneider D, Naclerio RM, Ober C.
A multiple splitting approach to linkage analysis in large pedigrees identifies a linkage to asthma on chromosome 12.
Bellenguez C, Ober C, Bourgain C.
A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q.
Pinto JM, Hayes MG, Schneider D, Naclerio RM, Ober C.
A common cortactin gene variation confers differential susceptibility to severe asthma.
Ma SF, Flores C, Wade MS, Dudek SM, Nicolae DL, Ober C, Garcia JG.
Fine mapping of a locus for nonsyndromic mental retardation on chromosome 19p13.
Nolan DK, Chen P, Das S, Ober C, Waggoner D.
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF Jr, Nicolae DL, Elias JA, Chupp GL.
A genome-wide screen for hyposmia susceptibility Loci.
Pinto JM, Thanaviratananich S, Hayes MG, Naclerio RM, Ober C.
(2008)
Chem Senses. 33(4):319-29. doi: 10.1093/chemse/bjm092. Epub 2008 Feb 2.
PMID: 18245794High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans.
Coop G, Wen X, Ober C, Pritchard JK, Przeworski M.
(2008)
Science. 319(5868):1395-8. doi: 10.1126/science.1151851. Epub 2008 Jan 31.
PMID: 18239090Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, Gudbjartsson D, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Blondal T, Jakobsdottir M, Stacey SN, Kostic J, Kristinsson KT, Birgisdottir B, Ghosh S, Magnusdottir DN, Thorlacius S, Thorleifsson G, Zheng SL, Sun J, Chang BL, Elmore JB, Breyer JP, McReynolds KM, Bradley KM, Yaspan BL, Wiklund F, Stattin P, Lindström S, Adami HO, McDonnell SK, Schaid DJ, Cunningham JM, Wang L, Cerhan JR, St Sauver JL, Isaacs SD, Wiley KE, Partin AW, Walsh PC, Polo S, Ruiz-Echarri M, Navarrete S, Fuertes F, Saez B, Godino J, Weijerman PC, Swinkels DW, Aben KK, Witjes JA, Suarez BK, Helfand BT, Frigge ML, Kristjansson K, Ober C, Jonsson E, Einarsson GV, Xu J, Gronberg H, Smith JR, Thibodeau SN, Isaacs WB, Catalona WJ, Mayordomo JI, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K.
Empirical data about women's attitudes towards a hypothetical pediatric biobank.
Neidich AB, Joseph JW, Ober C, Ross LF.
(2008)
Am J Med Genet A. 146A(3):297-304. doi: 10.1002/ajmg.a.32145.
PMID: 18205141Empirical data about women's attitudes toward a biobank focused on pregnancy outcomes.
Joseph JW, Neidich AB, Ober C, Ross LF.
(2008)
Am J Med Genet A. 146A(3):305-11. doi: 10.1002/ajmg.a.32146.
PMID: 18203186CFTR mutations and reproductive outcomes in a population isolate.
Gallego Romero I, Ober C.
(2008)
Hum Genet. 122(6):583-8. doi: 10.1007/s00439-007-0432-1. Epub 2007 Sep 28.
PMID: 17901983Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, Ober C.
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
Gudmundsson J, Sulem P, Steinthorsdottir V, Bergthorsson JT, Thorleifsson G, Manolescu A, Rafnar T, Gudbjartsson D, Agnarsson BA, Baker A, Sigurdsson A, Benediktsdottir KR, Jakobsdottir M, Blondal T, Stacey SN, Helgason A, Gunnarsdottir S, Olafsdottir A, Kristinsson KT, Birgisdottir B, Ghosh S, Thorlacius S, Magnusdottir D, Stefansdottir G, Kristjansson K, Bagger Y, Wilensky RL, Reilly MP, Morris AD, Kimber CH, Adeyemo A, Chen Y, Zhou J, So WY, Tong PC, Ng MC, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Tres A, Fuertes F, Ruiz-Echarri M, Asin L, Saez B, van Boven E, Klaver S, Swinkels DW, Aben KK, Graif T, Cashy J, Suarez BK, van Vierssen Trip O, Frigge ML, Ober C, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Palmer CN, Rotimi C, Chan JC, Pedersen O, Sigurdsson G, Benediktsson R, Jonsson E, Einarsson GV, Mayordomo JI, Catalona WJ, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K.
(2007)
Nat Genet. 39(8):977-83. doi: 10.1038/ng2062. Epub 2007 Jul 1.
PMID: 17603485Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness.
Pluzhnikov A, Nolan DK, Tan Z, McPeek MS, Ober C.
Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life.
Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C.
(2007)
J Allergy Clin Immunol. 119(6):1423-9. doi: 10.1016/j.jaci.2007.03.029.
PMID: 17556058Heritability estimation of sex-specific effects on human quantitative traits.
Pan L, Ober C, Abney M.
(2007)
Genet Epidemiol. 31(4):338-47. doi: 10.1002/gepi.20214.
PMID: 17323368A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans.
Flores C, Ma SF, Maresso K, Ober C, Garcia JG.
(2007)
Genet Epidemiol. 31(4):296-305. doi: 10.1002/gepi.20210.
PMID: 17266121Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
Gudmundsson J, Sulem P, Manolescu A, Amundadottir LT, Gudbjartsson D, Helgason A, Rafnar T, Bergthorsson JT, Agnarsson BA, Baker A, Sigurdsson A, Benediktsdottir KR, Jakobsdottir M, Xu J, Blondal T, Kostic J, Sun J, Ghosh S, Stacey SN, Mouy M, Saemundsdottir J, Backman VM, Kristjansson K, Tres A, Partin AW, Albers-Akkers MT, Godino-Ivan Marcos J, Walsh PC, Swinkels DW, Navarrete S, Isaacs SD, Aben KK, Graif T, Cashy J, Ruiz-Echarri M, Wiley KE, Suarez BK, Witjes JA, Frigge M, Ober C, Jonsson E, Einarsson GV, Mayordomo JI, Kiemeney LA, Isaacs WB, Catalona WJ, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K.
(2007)
Nat Genet. 39(5):631-7. doi: 10.1038/ng1999. Epub 2007 Apr 1.
PMID: 17401366The development and validation of the Indigenous Risk Impact Screen (IRIS): a 13-item screening instrument for alcohol and drug and mental health risk.
Schlesinger CM, Ober C, McCarthy MM, Watson JD, Seinen A.
Genetic studies of stuttering in a founder population.
Wittke-Thompson JK, Ambrose N, Yairi E, Roe C, Cook EH, Ober C, Cox NJ.
Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility.
Weiss LA, Kosova G, Delahanty RJ, Jiang L, Cook EH, Ober C, Sutcliffe JS.
(2006)
Eur J Hum Genet. 14(8):923-31. doi: 10.1038/sj.ejhg.5201644. Epub 2006 May 17.
PMID: 16724005ITGB3 shows genetic and expression interaction with SLC6A4.
Weiss LA, Ober C, Cook EH Jr.
(2006)
Hum Genet. 120(1):93-100. doi: 10.1007/s00439-006-0196-z. Epub 2006 May 24.
PMID: 16721604Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Kurz T, Hoffjan S, Hayes MG, Schneider D, Nicolae R, Heinzmann A, Jerkic SP, Parry R, Cox NJ, Deichmann KA, Ober C.
(2006)
J Allergy Clin Immunol. 118(2):396-402. doi: 10.1016/j.jaci.2006.04.036. Epub 2006 Jun 9.
PMID: 16890764The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells.
Ober C, Billstrand C, Kuldanek S, Tan Z.
A common variant associated with prostate cancer in European and African populations.
Amundadottir LT, Sulem P, Gudmundsson J, Helgason A, Baker A, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Cazier JB, Sainz J, Jakobsdottir M, Kostic J, Magnusdottir DN, Ghosh S, Agnarsson K, Birgisdottir B, Le Roux L, Olafsdottir A, Blondal T, Andresdottir M, Gretarsdottir OS, Bergthorsson JT, Gudbjartsson D, Gylfason A, Thorleifsson G, Manolescu A, Kristjansson K, Geirsson G, Isaksson H, Douglas J, Johansson JE, Bälter K, Wiklund F, Montie JE, Yu X, Suarez BK, Ober C, Cooney KA, Gronberg H, Catalona WJ, Einarsson GV, Barkardottir RB, Gulcher JR, Kong A, Thorsteinsdottir U, Stefansson K.
(2006)
Nat Genet. 38(6):652-8. doi: 10.1038/ng1808. Epub 2006 May 7.
PMID: 16682969Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.
Ober C, Pan L, Phillips N, Parry R, Kurina LM.
(2006)
Curr Allergy Asthma Rep. 6(3):241-6. doi: 10.1007/s11882-006-0041-4.
PMID: 16579875Variation in the type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy.
Chan A, Newman DL, Shon AM, Schneider DH, Kuldanek S, Ober C.
Asthma genetics the long and winding road to gene discovery.
Ober C, Hoffjan S.
The sex-specific genetic architecture of quantitative traits in humans.
Weiss LA, Pan L, Abney M, Ober C.
(2006)
Nat Genet. 38(2):218-22. doi: 10.1038/ng1726. Epub 2006 Jan 22.
PMID: 16429159A genome-wide search for quantitative trait loci contributing to variation in seasonal pollen reactivity.
Blumenthal MN, Langefeld CD, Barnes KC, Ober C, Meyers DA, King RA, Beaty TH, Beck SR, Bleecker ER, Rich SS; Collaborative Study on the Genetics of Asthma.
(2006)
J Allergy Clin Immunol. 117(1):79-85. doi: 10.1016/j.jaci.2005.09.038.
PMID: 16387588Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy.
Donfack J, Schneider DH, Tan Z, Kurz T, Dubchak I, Frazer KA, Ober C.
Rethinking genetic models of asthma: the role of environmental modifiers.
Ober C, Thompson EE.
(2005)
Curr Opin Immunol. 17(6):670-8. doi: 10.1016/j.coi.2005.09.009. Epub 2005 Oct 7.
PMID: 16214315Evidence of balancing selection at the HLA-G promoter region.
Tan Z, Shon AM, Ober C.
(2005)
Hum Mol Genet. 14(23):3619-28. doi: 10.1093/hmg/ddi389. Epub 2005 Oct 19.
PMID: 16236759HLA-G: an asthma gene on chromosome 6p.
Ober C.
(2005)
Immunol Allergy Clin North Am. 25(4):669-79. doi: 10.1016/j.iac.2005.08.001.
PMID: 16257632Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals.
Zhang J, Schneider D, Ober C, McPeek MS.
(2005)
Genet Epidemiol. 29(2):128-40. doi: 10.1002/gepi.20081.
PMID: 16049966Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.
Shilling RA, Pinto JM, Decker DC, Schneider DH, Bandukwala HS, Schneider JR, Camoretti-Mercado B, Ober C, Sperling AI.
(2005)
J Immunol. 175(4):2061-5. doi: 10.4049/jimmunol.175.4.2061.
PMID: 16081771Perspectives on the past decade of asthma genetics.
Ober C.
(2005)
J Allergy Clin Immunol. 116(2):274-8. doi: 10.1016/j.jaci.2005.04.039.
PMID: 16083779Sex differences in the genetic basis of morning serum cortisol levels: genome-wide screen identifies two novel loci specific to women.
Kurina LM, Weiss LA, Graves SW, Parry R, Williams GH, Abney M, Ober C.
(2005)
J Clin Endocrinol Metab. 90(8):4747-52. doi: 10.1210/jc.2005-0384. Epub 2005 Jun 7.
PMID: 15941864Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Weiss LA, Lester LA, Gern JE, Wolf RL, Parry R, Lemanske RF, Solway J, Ober C.
Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample.
Weiss LA, Abney M, Parry R, Scanu AM, Cook EH Jr, Ober C.
(2005)
Hum Genet. 117(1):81-7. doi: 10.1007/s00439-004-1250-3. Epub 2005 Apr 15.
PMID: 15834589HLA-G and immune tolerance in pregnancy.
Hunt JS, Petroff MG, McIntire RH, Ober C.
(2005)
FASEB J. 19(7):681-93. doi: 10.1096/fj.04-2078rev.
PMID: 15857883Gene-environment interaction effects on the development of immune responses in the 1st year of life.
Hoffjan S, Nicolae D, Ostrovnaya I, Roberg K, Evans M, Mirel DB, Steiner L, Walker K, Shult P, Gangnon RE, Gern JE, Martinez FD, Lemanske RF, Ober C.
Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Nicolae D, Cox NJ, Lester LA, Schneider D, Tan Z, Billstrand C, Kuldanek S, Donfack J, Kogut P, Patel NM, Goodenbour J, Howard T, Wolf R, Koppelman GH, White SR, Parry R, Postma DS, Meyers D, Bleecker ER, Hunt JS, Solway J, Ober C.
Sex-specific genetic architecture of whole blood serotonin levels.
Weiss LA, Abney M, Cook EH Jr, Ober C.
Human body scents: conscious perceptions and biological effects.
McClintock MK, Bullivant S, Jacob S, Spencer N, Zelano B, Ober C.
(2005)
Chem Senses. 30 Suppl 1:i135-7. doi: 10.1093/chemse/bjh151.
PMID: 15738077Testing for Hardy-Weinberg equilibrium in samples with related individuals.
Bourgain C, Abney M, Schneider D, Ober C, McPeek MS.
Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin.
Weiss LA, Veenstra-Vanderweele J, Newman DL, Kim SJ, Dytch H, McPeek MS, Cheng S, Ober C, Cook EH Jr, Abney M.
(2004)
Eur J Hum Genet. 12(11):949-54. doi: 10.1038/sj.ejhg.5201239.
PMID: 15292919The role of environmental tobacco smoke in genetic susceptibility to asthma.
Kurz T, Ober C.
(2004)
Curr Opin Allergy Clin Immunol. 4(5):335-9. doi: 10.1097/00130832-200410000-00002.
PMID: 15349030Inheritance of most X-linked traits is not dominant or recessive, just X-linked.
Dobyns WB, Filauro A, Tomson BN, Chan AS, Ho AW, Ting NT, Oosterwijk JC, Ober C.
(2004)
Am J Med Genet A. 129A(2):136-43. doi: 10.1002/ajmg.a.30123.
PMID: 15316978Are common disease susceptibility alleles the same in outbred and founder populations?
Newman DL, Hoffjan S, Bourgain C, Abney M, Nicolae RI, Profits ET, Grow MA, Walker K, Steiner L, Parry R, Reynolds R, McPeek MS, Cheng S, Ober C.
(2004)
Eur J Hum Genet. 12(7):584-90. doi: 10.1038/sj.ejhg.5201191.
PMID: 15100713Best linear unbiased allele-frequency estimation in complex pedigrees.
McPeek MS, Wu X, Ober C.
(2004)
Biometrics. 60(2):359-67. doi: 10.1111/j.0006-341X.2004.00180.x.
PMID: 15180661Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA).
Blumenthal MN, Ober C, Beaty TH, Bleecker ER, Langefeld CD, King RA, Lester L, Cox N, Barnes K, Togias A, Mathias R, Meyers DA, Oetting W, Rich SS; CSGA.
Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis?
Reed AM, McNallan K, Wettstein P, Vehe R, Ober C.
(2004)
J Immunol. 172(8):5041-6. doi: 10.4049/jimmunol.172.8.5041.
PMID: 15067086Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy.
Hoffjan S, Ostrovnaja I, Nicolae D, Newman DL, Nicolae R, Gangnon R, Steiner L, Walker K, Reynolds R, Greene D, Mirel D, Gern JE, Lemanske RF Jr, Ober C.
(2004)
J Allergy Clin Immunol. 113(3):511-8. doi: 10.1016/j.jaci.2003.10.044.
PMID: 15007355Effects of dog ownership and genotype on immune development and atopy in infancy.
Gern JE, Reardon CL, Hoffjan S, Nicolae D, Li Z, Roberg KA, Neaville WA, Carlson-Dakes K, Adler K, Hamilton R, Anderson E, Gilbertson-White S, Tisler C, Dasilva D, Anklam K, Mikus LD, Rosenthal LA, Ober C, Gangnon R, Lemanske RF Jr.
(2004)
J Allergy Clin Immunol. 113(2):307-14. doi: 10.1016/j.jaci.2003.11.017.
PMID: 14767447Evidence for extensive transmission distortion in the human genome.
Zöllner S, Wen X, Hanchard NA, Herbert MA, Ober C, Pritchard JK.
A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma.
Blumenthal MN, Langefeld CD, Beaty TH, Bleecker ER, Ober C, Lester L, Lange E, Barnes KC, Wolf R, King RA, Solway J, Oetting W, Meyers DA, Rich SS.
(2004)
Hum Genet. 114(2):157-64. doi: 10.1007/s00439-003-1030-5. Epub 2003 Oct 25.
PMID: 14586638Prodromal angina reduces infarcted mass less in interventionally reperfused than in thrombolysed myocardial infarction.
Ober MC, Ober C, Hagău A, Moţ S, Iancu A, Literat S, Căpâlneanu R.
Association studies for asthma and atopic diseases: a comprehensive review of the literature.
Hoffjan S, Nicolae D, Ober C.
Immunogenicity of the soluble isoforms of HLA-G.
Hunt JS, Pace JL, Morales PJ, Ober C.
Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus.
Bourgain C, Hoffjan S, Nicolae R, Newman D, Steiner L, Walker K, Reynolds R, Ober C, McPeek MS.
Variation in the HLA-G promoter region influences miscarriage rates.
Ober C, Aldrich CL, Chervoneva I, Billstrand C, Rahimov F, Gray HL, Hyslop T.
Pregnancy outcome in recurrent miscarriage patients with skewed X chromosome inactivation.
Sullivan AE, Lewis T, Stephenson M, Odem R, Schreiber J, Ober C, Branch DW.
(2003)
Obstet Gynecol. 101(6):1236-42. doi: 10.1016/s0029-7844(03)00345-4.
PMID: 12798530Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure.
Colilla S, Nicolae D, Pluzhnikov A, Blumenthal MN, Beaty TH, Bleecker ER, Lange EM, Rich SS, Meyers DA, Ober C, Cox NJ; Collaborative Study for the Genetics of Asthma.
(2003)
J Allergy Clin Immunol. 111(4):840-6. doi: 10.1067/mai.2003.170.
PMID: 12704367Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.
Donfack J, Kogut P, Forsythe S, Solway J, Ober C.
(2003)
J Allergy Clin Immunol. 111(3):527-32. doi: 10.1067/mai.2003.71.
PMID: 12642833Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree.
Newman DL, Abney M, Dytch H, Parry R, McPeek MS, Ober C.
(2003)
Hum Mol Genet. 12(2):137-44. doi: 10.1093/hmg/ddg012.
PMID: 12499394Present status on the genetic studies of asthma.
Hoffjan S, Ober C.
(2002)
Curr Opin Immunol. 14(6):709-17. doi: 10.1016/s0952-7915(02)00393-x.
PMID: 12413520Linkage disequilibrium and age estimates of a deletion polymorphism (1597DeltaC) in HLA-G suggest non-neutral evolution.
Aldrich C, Wambebe C, Odama L, Di Rienzo A, Ober C.
(2002)
Hum Immunol. 63(5):405-12. doi: 10.1016/s0198-8859(02)00377-4.
PMID: 11975984Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites.
Abney M, Ober C, McPeek MS.
Paternally inherited HLA alleles are associated with women's choice of male odor.
Jacob S, McClintock MK, Zelano B, Ober C.
(2002)
Nat Genet. 30(2):175-9. doi: 10.1038/ng830. Epub 2002 Jan 22.
PMID: 11799397Missing data in haplotype analysis: a study on the MILC method.
Bourgain C, Genin E, Ober C, Clerget-Darpoux F.
Three polymorphisms in the 3' UTR of the TRAIL (TNF-related apoptosis-inducing ligand) gene.
Gray HL, Sorensen EL, Hunt JS, Ober C.
HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage.
Aldrich CL, Stephenson MD, Karrison T, Odem RR, Branch DW, Scott JR, Schreiber JR, Ober C.
The importance of genealogy in determining genetic associations with complex traits.
Newman DL, Abney M, McPeek MS, Ober C, Cox NJ.
(2001)
Am J Hum Genet. 69(5):1146-8. No abstract available.
PMID: 11590549The genetic dissection of complex traits in a founder population.
Ober C, Abney M, McPeek MS.
(2001)
Am J Hum Genet. 69(5):1068-79. Epub 2001 Oct 3. Erratum in: Am J Hum Genet 2002 Jan;70(1):284.
PMID: 11590547Ethnic differences in asthma and associated phenotypes: collaborative study on the genetics of asthma.
Lester LA, Rich SS, Blumenthal MN, Togias A, Murphy S, Malveaux F, Miller ME, Dunston GM, Solway J, Wolf RL, Samet JM, Marsh DG, Meyers DA, Ober C, Bleecker ER; Collaborative Study on the Genetics of Asthma.
Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma.
Xu J, Meyers DA, Ober C, Blumenthal MN, Mellen B, Barnes KC, King RA, Lester LA, Howard TD, Solway J, Langefeld CD, Beaty TH, Rich SS, Bleecker ER, Cox NJ; Collaborative Study on the Genetics of Asthma.
(2001)
Am J Hum Genet. 68(6):1437-46. Epub 2001 May 10.
PMID: 11349227Broad and narrow heritabilities of quantitative traits in a founder population.
Abney M, McPeek MS, Ober C.
A population genetics study of single nucleotide polymorphisms in the interleukin 4 receptor alpha (IL4RA) gene.
Wu X, Di Rienzo A, Ober C.
A novel polymorphism in the 5' promoter region of the human interleukin-4 receptor alpha-chain gene is associated with decreased soluble interleukin-4 receptor protein levels.
Hackstein H, Hecker M, Kruse S, Bohnert A, Ober C, Deichmann KA, Bein G.
Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families.
Mathias RA, Freidhoff LR, Blumenthal MN, Meyers DA, Lester L, King R, Xu JF, Solway J, Barnes KC, Pierce J, Stine OC, Togias A, Oetting W, Marshik PL, Hetmanski JB, Huang SK, Ehrlich E, Dunston GM, Malveaux F, Banks-Schlegel S, Cox NJ, Bleecker E, Ober C, Beaty TH, Rich SS; CSGA (Collaborative Study of the Genetics of Asthma).
Susceptibility genes in asthma and allergy.
Ober C.
Description of three data sets: Collaborative Study on the Genetics of Asthma (CSGA), the German Affected-Sib-Pair Study, and the Hutterites of South Dakota.
Meyers DA, Wjst M, Ober C.
A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.
Ober C, Tsalenko A, Parry R, Cox NJ.
HLA-G in reproduction: studies on the maternal-fetal interface.
Hunt JS, Petroff MG, Morales P, Sedlmayr P, Geraghty DE, Ober C.
Soluble HLA-G circulates in maternal blood during pregnancy.
Hunt JS, Jadhav L, Chu W, Geraghty DE, Ober C.
Cross-species amplification, non-invasive genotyping, and non-Mendelian inheritance of human STRPs in Savannah baboons.
Smith KL, Alberts SC, Bayes MK, Bruford MW, Altmann J, Ober C.
beta(2)-adrenergic receptor Arg16/Arg16 genotype is associated with reduced lung function, but not with asthma, in the Hutterites.
Summerhill E, Leavitt SA, Gidley H, Parry R, Solway J, Ober C.
Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites.
Eklund AC, Belchak MM, Lapidos K, Raha-Chowdhury R, Ober C.
Contributing factors to the pathobiology. The genetics of asthma.
Ober C, Moffatt MF.
HLA-DRB1*01 alleles are associated with sensitization to cockroach allergens.
Donfack J, Tsalenko A, Hoki DM, Parry R, Solway J, Lester LA, Ober C.
A null mutation in HLA-G is not associated with preeclampsia or intrauterine growth retardation.
Aldrich C, Verp MS, Walker MA, Ober C.
Estimation of variance components of quantitative traits in inbred populations.
Abney M, McPeek MS, Ober C.
Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.
Ober C, Leavitt SA, Tsalenko A, Howard TD, Hoki DM, Daniel R, Newman DL, Wu X, Parry R, Lester LA, Solway J, Blumenthal M, King RA, Xu J, Meyers DA, Bleecker ER, Cox NJ.
A robust test for assortative mating.
Génin E, Ober C, Weitkamp L, Thomson G.
Polymorphic microsatellite markers within the MHC of Peromyscus polionotus.
Eklund AC, Ober C.
(2000)
Hereditas. 133(2):179-81. No abstract available.
PMID: 11338432Genome-wide screen for atopy susceptibility alleles in the Hutterites.
Ober C, Tsalenko A, Willadsen S, Newman D, Daniel R, Wu X, Andal J, Hoki D, Schneider D, True K, Schou C, Parry R, Cox N.
Determination of Duffy genotypes in three populations of African descent using PCR and sequence-specific oligonucleotides.
Nickel RG, Willadsen SA, Freidhoff LR, Huang SK, Caraballo L, Naidu RP, Levett P, Blumenthal M, Banks-Schlegel S, Bleecker E, Beaty T, Ober C, Barnes KC.
Mononuclear-cell immunisation in prevention of recurrent miscarriages: arandomised trial.
Ober C, Karrison T, Odem RR, Barnes RB, Branch DW, Stephenson MD, Baron B, Walker MA, Scott JR, Schreiber JR.
Ancestral and recombinant 16-locus HLA haplotypes in the Hutterites.
Weitkamp LR, Ober C.
Studies of HLA, fertility and mate choice in a human isolate.
Ober C.
Inbreeding effects on fertility in humans: evidence for reproductive compensation.
Ober C, Hyslop T, Hauck WW.
Effect of inbreeding avoidance on Hardy-Weinberg expectations: examples of neutral and selected loci.
Robertson A, Charlesworth D, Ober C.
The CTLA-4 gene is expressed in placental fibroblasts.
Kaufman KA, Bowen JA, Tsai AF, Bluestone JA, Hunt JS, Ober C.
HLA-H: a pseudogene with increased variation due to balancing selection at neighboring loci.
Grimsley C, Mather KA, Ober C.
Transmission disequilibrium of maternally-inherited CTLA-4 microsatellite alleles in idiopathic recurrent miscarriage.
Tsai AF, Kaufman KA, Walker MA, Karrison TG, Odem RR, Barnes RB, Scott JR, Schreiber JR, Stephenson MD, Ober C.
Recurrent miscarriage (REMIS) study: how should data from women who do not become pregnant be handled?
Karrison TG, Ober C.
HLA-G polymorphisms: ethnic differences and implications for potential molecule function.
van der Ven K, Skrablin S, Ober C, Krebs D.
Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma.
Ober C, Cox NJ, Abney M, Di Rienzo A, Lander ES, Changyaleket B, Gidley H, Kurtz B, Lee J, Nance M, Pettersson A, Prescott J, Richardson A, Schlenker E, Summerhill E, Willadsen S, Parry R.
Expression and cytogenetic localization of the human SM22 gene (TAGLN).
Camoretti-Mercado B, Forsythe SM, LeBeau MM, Espinosa R 3rd, Vieira JE, Halayko AJ, Willadsen S, Kurtz B, Ober C, Evans GA, Thweatt R, Shapiro S, Niu Q, Qin Y, Padrid PA, Solway J.
Immunogenetic studies in families of children with juvenile dermatomyositis.
Reed AM, Pachman LM, Hayford J, Ober C.
The genetics of asthma. Mapping genes for complex traits in founder populations.
Ober C, Cox NJ.
(1998)
Clin Exp Allergy. 28 Suppl 1:101-5; discussion 108-10. No abstract available.
PMID: 9641605HLA-G1 protein expression is not essential for fetal survival.
Ober C, Aldrich C, Rosinsky B, Robertson A, Walker MA, Willadsen S, Verp MS, Geraghty DE, Hunt JS.
Microchimerism and HLA-compatible relationships of pregnancy in scleroderma.
Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, Bean MA, Ober C, Bianchi DW.
Do genetics play a role in the pathogenesis of asthma?
Ober C.
(1998)
J Allergy Clin Immunol. 101(2 Pt 2):S417-20. Review. No abstract available.
PMID: 9500742HLA and pregnancy: the paradox of the fetal allograft.
Ober C.
(1998)
Am J Hum Genet. 62(1):1-5. Review. No abstract available.
PMID: 9443885Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study.
Ober C, Hyslop T, Elias S, Weitkamp LR, Hauck WW.
Evaluating the role of Th0 and Th1 clones in autoimmune thyroid disease by use of Hu-SCID chimeras.
Fisfalen ME, Soltani K, Kaplan E, Palmer EM, van Seventer GA, Straus FH, Diaz M, Ober C, DeGroot LJ.
HLA-G polymorphisms: neutral evolution or novel function?
Ober C, Aldrich CL.
Thyrotropin-receptor and thyroid peroxidase-specific T cell clones and their cytokine profile in autoimmune thyroid disease.
Fisfalen ME, Palmer EM, Van Seventer GA, Soltani K, Sawai Y, Kaplan E, Hidaka Y, Ober C, DeGroot LJ.
HLA and mate choice in humans.
Ober C, Weitkamp LR, Cox N, Dytch H, Kostyu D, Elias S.
A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA).
Collaborative Study on the Genetics of Asthma (CSGA) [C. Ober, corresponding author].
Immunogenetics of reproduction: an overview.
Ober C, van der Ven K.
(1997)
Curr Top Microbiol Immunol. 222:1-23. Review. No abstract available.
PMID: 9257483Population genetic studies of HLA-E: evidence for selection.
Grimsley C, Ober C.
Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A1.
Ober C, Rosinsky B, Grimsley C, van der Ven K, Robertson A, Runge A.
(1996)
J Reprod Immunol. 32(2):111-23. Erratum in: J Reprod Immunol 1997 Apr;33(1):89-90.
PMID: 9023816Cystic fibrosis mutation screening in healthy men with reduced sperm quality.
van der Ven K, Messer L, van der Ven H, Jeyendran RS, Ober C.
HLA and fertility.
Ober C.
(1995)
Am J Hum Genet. 57(5):1242-3. No abstract available.
PMID: 7485176Collaborative studies on the genetics of asthma--National Heart, Lung and Blood Institute.
Blumenthal MN, Banks-Schlegel S, Bleecker ER, Marsh DG, Ober C.
(1995)
Clin Exp Allergy. 25 Suppl 2:29-32. No abstract available.
PMID: 8590337Current topic: HLA and reproduction: lessons from studies in the Hutterites.
Ober C.
HLA-DQA1 and HLA-DQB1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion.
Steck T, van der Ven K, Kwak J, Beer A, Ober C.
Prioritizing asthma research: the need to investigate childhood asthma.
Geppert EF, Lester LA, Ober C.
(1995)
Am J Respir Crit Care Med. 151(5):1294-5. No abstract available.
PMID: 7735577Extended HLA profile of an inbred isolate: the Schmiedeleut Hutterites of South Dakota.
Dawson DV, Ober C, Kostyu DD.
HLA-G polymorphisms in African Americans.
van der Ven K, Ober C.
Analysis of HLA haplotype segregation in the Schmiedeleut Hutterites of South Dakota.
Bryttan JM, Kostyu DD, Ober C, Elias S, Dawson DV.
Delta F508 genotype does not predict disease severity in an ethnically diverse cystic fibrosis population.
Lester LA, Kraut J, Lloyd-Still J, Karrison T, Mott C, Billstrand C, Lemke A, Ober C.
MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion.
Ober C, Steck T, van der Ven K, Billstrand C, Messer L, Kwak J, Beaman K, Beer A.
Autoantibodies and pregnancy history in a healthy population.
Ober C, Karrison T, Harlow L, Elias S, Gleicher N.
Deficit of HLA homozygotes in a Caucasian isolate.
Kostyu DD, Dawson DV, Elias S, Ober C.
Maternal-fetal histocompatibility in intrauterine growth retarded and normal weight babies.
Verp MS, Sibul M, Billstrand C, Bellen G, Hsu M, Ober C.
Sex-biased lactational duration in a human population and its reproductive costs.
Margulis SW, Altmann J, Ober C.
Ethnic heterogeneity and cystic fibrosis transmembrane regulator (CFTR) mutation frequencies in Chicago-area CF families.
Ober C, Lester LA, Mott C, Billstrand C, Lemke A, van der Ven K, Marcus S, Kraut J, Lloyd-Still J, Booth C.
Increased risk for polycystic ovary syndrome associated with human leukocyte antigen DQA1*0501.
Ober C, Weil S, Steck T, Billstrand C, Levrant S, Barnes R.
Chimerism as the etiology of a 46,XX/46,XY fertile true hermaphrodite.
Verp MS, Harrison HH, Ober C, Oliveri D, Amarose AP, Lindgren V, Talerman A.
Decreased fecundability in Hutterite couples sharing HLA-DR.
Ober C, Elias S, Kostyu DD, Hauck WW.
The maternal-fetal relationship in human pregnancy: an immunogenetic perspective.
Ober C.
Molecular genetic studies of major histocompatibility complex genes in children with juvenile dermatomyositis: increased risk associated with HLA-DQA1 *0501.
Reed AM, Pachman L, Ober C.
Correlation of phenotypic and genetic heterogeneity in cystic fibrosis: variability in sweat electrolyte levels contributes to heterogeneity and is increased with the XV-2c/KM19 B haplotype.
Witt M, Erickson RP, Ober C, Howatt WF, Farber R.
Delayed diagnosis of pseudohermaphroditism on stored blood spot.
Verp MS, Ober C, Oliveri DR, Israel J.
(1991)
Lancet. 337(8748):1037. No abstract available.
PMID: 1673185Identification of a serum protein polymorphism via two-dimensional electrophoresis. Family and population studies in two genetically isolated groups: North American Hutterites and Australian aborigines.
Harrison H, Miller K, Ober C, Refetoff S, Dick M, Elias S.
Statistical analysis of outcomes from repeated pregnancies: effects of HLA sharing on fetal loss rates.
Hauck WW, Ober C.
Translocations are infrequent among couples having repeated spontaneous abortions but no other abnormal pregnancies.
Simpson JL, Meyers CM, Martin AO, Elias S, Ober C.
Increased risk for gestational diabetes mellitus associated with insulin receptor and insulin-like growth factor II restriction fragment length polymorphisms.
Ober C, Xiang KS, Thisted RA, Indovina KA, Wason CJ, Dooley S.
HLA sharing and fertility in Hutterite couples: evidence for prenatal selection against compatible fetuses.
Ober C, Elias S, O'Brien E, Kostyu DD, Hauck WW, Bombard A.
Autoimmune etiology in premature ovarian failure.
LaBarbera AR, Miller MM, Ober C, Rebar RW.
(1988)
Am J Reprod Immunol Microbiol. 16(3):115-22. Review. No abstract available.
PMID: 3289410Studies of cystic fibrosis in Hutterite families by using linked DNA probes.
Ober C, Bombard A, Dhaliwal R, Elias S, Fagan J, Laffler TG, Martin AO, Rosinsky B.
Restriction fragment length polymorphisms of the insulin gene hypervariable region in gestational onset diabetes mellitus.
Ober C, Wason CJ, Andrew K, Dooley S.
Prenatal effects of maternal-fetal HLA compatibility.
Ober C, Simpson JL, Ward M, Radvany RM, Andersen R, Elias S, Sabbagha R.
The human sex ratio: increase in first-born males to parents with shared HLA-DR antigens.
Radvany RM, Vaisrub N, Ober C, Patel KM, Hecht F.
Maternal serum alpha-fetoprotein screening: low and high values for detection of genetic abnormalities.
Simpson JL, Baum LD, Marder R, Elias S, Ober C, Martin AO.
Diabetes mellitus: preventing anomalies through maternal metabolic intervention.
Ober C, Simpson JL.
(1986)
Clin Obstet Gynecol. 29(3):558-68. No abstract available.
PMID: 2428552Gestational diabetes mellitus: a syndrome with phenotypic and genotypic heterogeneity.
Freinkel N, Metzger BE, Phelps RL, Simpson JL, Martin AO, Radvany R, Ober C, Dooley SL, Depp RO, Belton A.
Increased male-to-female sex ratio among HLA-DR compatible pregnancies.
Ober C, Simpson JL, Radvany R.
Frequency of diabetes mellitus in mothers of probands with gestational diabetes: possible maternal influence on the predisposition to gestational diabetes.
Martin AO, Simpson JL, Ober C, Freinkel N.